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Article

Donor CYP3A5 Expression Decreases Renal Transplantation Outcomes in White Renal Transplant Recipients.

Annals of transplantation - 26 Jul 2022

Warzyszyńska Karola, Zawistowski Michał, Karpeta Edyta, Jałbrzykowska Agnieszka, Kosieradzki Maciej

Abstract excerpt

BACKGROUND After renal transplantation, immunosuppressants should be administered to prevent organ rejection and prolong graft survival. One of them is tacrolimus, which is metabolized by the CYP3A enzyme family. The variability of the CYP3A5 gene in renal transplant recipients has been previously studied for its correlation with acute rejection and allogeneic kidney function. CYP3A5 enzyme is also present in the...

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Share to Cytochrome P-450 CYP3A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35879888
DOI: 10.12659/AOT.936276
PMCID: PMC9339223

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