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Article

Effect of CYP3A5 polymorphism on the pharmacokinetics of tacrolimus and acute rejection in renal transplant recipients: experience at a single centre.

International journal of clinical practice. Supplement - 1 May 2015

Cheng Y, Li H, Meng Y, Liu H, Yang L, Xu T, Yu J, Zhao N, Liu Y

Abstract excerpt

AIM: As a substrate of cytochrome P450 (CYP) 3A5, tacrolimus is characterised by a narrow therapeutic index and large inter-individual variability. Our objective was to determine the influence of CYP3A5 genetic polymorphisms on tacrolimus pharmacokinetics and acute rejection in Chinese renal transplant recipients. METHODS: Thirty-five renal recipients treated with tacrolimus in our centre were genotyped for...

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Source

Identifiers

PMID: 26177012
DOI: 10.1111/ijcp.12662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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