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Article

Lack of tacrolimus circadian pharmacokinetics and CYP3A5 pharmacogenetics in the early and maintenance stages in Japanese renal transplant recipients.

British journal of clinical pharmacology - 1 Aug 2008

Satoh Shigeru, Kagaya Hideaki, Saito Mitsuru, Inoue Takamitsu, Miura Masatomo, Inoue Kazuyuki, Numakura Kazuyuki, Tsuchiya Norihiko, Tada Hitoshi, Suzuki Toshio, Habuchi Tomonori

Abstract excerpt

AIMS: We investigated whether tacrolimus pharmacokinetics shows circadian variation and the influence of the CYP3A5 A6986G polymorphism on the pharmacokinetics in both the early and maintenance stages after renal transplantation. METHODS: Tacrolimus was administered twice daily at specified times (09.00 and 21.00 h) throughout the pre- and post-transplant period according to the trough-targeting strategy. Fifty...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18429967
DOI: 10.1111/j.1365-2125.2008.03188.x
PMCID: PMC2492917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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