Article
Identification of factors affecting tacrolimus level and 5-year clinical outcome in kidney transplant patients.
Basic & clinical pharmacology & toxicology - 1 Oct 2012
Kim In-Wha, Noh Hyejin, Ji Eunhee, Han Nayoung, Hong Su Hyun, Ha Jongwon, Burckart Gilbert J, Oh Jung Mi
Abstract excerpt
The purpose of this study was to identify and characterize the association of various clinical variables and CYP3A5 genotypes with the pharmacokinetics of tacrolimus and outcome over 1-5 years in kidney transplantation patients in Korea. A total of 129 recipients (aged 18-65 years) administered tacrolimus were genotyped for CYP3A5 (6986A>G in intron 3; rs776746). Clinical covariates and trough levels, doses and...
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