Article
Impact of the CYP3A5 genotype on the distributions of dose-adjusted trough concentrations and incidence of rejection in Japanese renal transplant recipients receiving different tacrolimus formulations.
Clinical and experimental nephrology - 1 Oct 2017
Niioka Takenori, Kagaya Hideaki, Saito Mitsuru, Inoue Takamitsu, Numakura Kazuyuki, Yamamoto Ryohei, Habuchi Tomonori, Satoh Shigeru, Miura Masatomo
Abstract excerpt
BACKGROUND: We investigated the impact of the CYP3A5 genotype on the distributions of dose-adjusted trough concentrations (C 0h/D) and the incidence of rejection in Japanese recipients taking twice-daily (Tac-BID, n = 140) or modified-release once-daily (Tac-QD, n = 80) tacrolimus formulations for 1 year after renal transplantation. METHODS: Logistic regression analysis was carried out to estimate the distinction...
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