Article
STAT4 polymorphism is associated with early-onset type 1 diabetes, but not with late-onset type 1 diabetes.
Annals of the New York Academy of Sciences - 1 Dec 2008
Lee Hye-Soon, Park Hyewon, Yang Seiwon, Kim Dukhee, Park Yongsoo
Abstract excerpt
In an effort to discover non-HLA genes affecting susceptibility to type 1 diabetes (T1D), we have investigated the association of polymorphisms in STAT4, an important signaling molecule of IL-12, gammaIFN, and IL-23, in a sample of 389 T1D patients and 152 nondiabetic controls in Korea. Four SNPs on chromosome 2q, which were recently found to be associated with rheumatoid arthritis, were examined for association...
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