The Impact of STAT3 rs1053005 Variation on Type 1 Diabetes Mellitus Susceptibility: Association Study and in Silico Analysis.

doi:10.1080/08820139.2022.2079419

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The Impact of STAT3 rs1053005 Variation on Type 1 Diabetes Mellitus Susceptibility: Association Study and in Silico Analysis.

Immunological investigations - 1 Aug 2022

Zandi Maryam, Moghaddam Vaha Akbary, Salehi Zivar, Mashayekhi Farhad, Dalili Setila

Abstract excerpt

AIMS: Type 1 diabetes (T1DM) is an autoimmune disorder with multiple genetic and environmental risk factors that are still poorly understood. The signal transducer and activator of transcription (STAT) proteins play a pivotal role in immune-cell genesis and regulation. This study aimed to determine the effect of rs1053005 single nucleotide polymorphism (SNP) in 3'-UTR of STAT3 mRNA on the susceptibility to T1DM...

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PMID: 35762640
DOI: 10.1080/08820139.2022.2079419

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