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Article

STAT4: genetics, mechanisms, and implications for autoimmunity.

Current allergy and asthma reports - 1 Sept 2008

Korman Benjamin D, Kastner Daniel L, Gregersen Peter K, Remmers Elaine F

Abstract excerpt

Recent advances in genetics and technology have led to breakthroughs in understanding the genes that predispose individuals to autoimmune diseases. A common haplotype of the signal transducer and activator of transcription 4 (STAT4) gene has been shown to be associated with susceptibility to rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren's syndrome. STAT4 is a transcription factor that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Lupus Erythematosus, Systemic

Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to STAT4 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 18682104
DOI: 10.1007/s11882-008-0077-8
PMCID: PMC2562257

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population.Semantic proximity Read ↗

Evidence for the role of STAT4 as a general autoimmunity locus in the Korean population.Semantic proximity Read ↗

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Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.Semantic proximity Read ↗

Association of STAT4 rs7574865 polymorphism with autoimmune diseases: a meta-analysis.Semantic proximity Read ↗

Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.Semantic proximity Read ↗

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STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.Semantic proximity Read ↗

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