Article
Association analysis between the TLR9 gene polymorphism rs352140 and type 1 diabetes.
Frontiers in endocrinology - 1 Jan 2023
Wang Yimeng, Xia Ying, Chen Yan, Xu Linling, Sun Xiaoxiao, Li Jiaqi, Huang Gan, Li Xia, Xie Zhiguo, Zhou Zhiguang
Abstract excerpt
Background: To a great extent, genetic factors contribute to the susceptibility to type 1 diabetes (T1D) development, and by triggering immune imbalance, Toll-like receptor (TLR) 9 is involved in the development of T1D. However, there is a lack of evidence supporting a genetic association between polymorphisms in the TLR9 gene and T1D. Methods: In total, 1513 individuals, including T1D patients (n=738) and...
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