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Article

Single nucleotide polymorphism rs 2070874 at Interleukin-4 is associated with increased risk of type 1 diabetes mellitus independently of human leukocyte antigens.

International journal of immunopathology and pharmacology - 1 Jan 2000

Osman Awad E, Brema Imad, AlQurashi Alaa, Al-Jurayyan Abdullah, Bradley Benjamin, Hamza Muaawia A

Abstract excerpt

INTRODUCTION: Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of insulin-producing pancreatic beta (β-) cells. Previous studies suggested an imbalance between and pro- and anti-inflammatory cytokines exacerbates T1DM development. OBJECTIVES: We aimed to test the hypothesis that patients with T1DM carry a higher frequency of regulatory genes associated with low levels of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35404688
DOI: 10.1177/03946320221090330
PMCID: PMC9006359

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