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Article

Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients.

Scientific reports - 6 Aug 2021

Qu Jingchun, Qu Hui-Qi, Bradfield Jonathan P, Glessner Joseph T, Chang Xiao, Tian Lifeng, March Michael, Connolly John J, Roizen Jeffrey D, Sleiman Patrick M A, Hakonarson Hakon

Abstract excerpt

With polygenic risk score (PRS) for autoimmune type 1 diabetes (T1D), this study identified T1D cases with low T1D PRS and searched for susceptibility loci in these cases. Our hypothesis is that genetic effects (likely mediated by relatively rare genetic variants) of non-mainstream (or non-autoimmune) T1D might have been diluted in the previous studies on T1D cases in general. Two cohorts for the PRS modeling and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34362956
DOI: 10.1038/s41598-021-94994-9
PMCID: PMC8346538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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