Article
Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes.
Frontiers in immunology - 1 Jan 2022
Gootjes Chelsea, Zwaginga Jaap Jan, Roep Bart O, Nikolic Tatjana
Abstract excerpt
Type 1 diabetes (T1D) is an autoimmune disease that develops in the interplay between genetic and environmental factors. A majority of individuals who develop T1D have a HLA make up, that accounts for 50% of the genetic risk of disease. Besides these HLA haplotypes and the insulin region that importantly contribute to the heritable component, genome-wide association studies have identified many polymorphisms in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.