Article
Evidence for the role of STAT4 as a general autoimmunity locus in the Korean population.
Diabetes/metabolism research and reviews - 1 Nov 2011
Park Yongsoo, Lee Hye-Soon, Park Youngjoo, Min Dongsoo, Yang Seiwon, Kim Dukhee, Cho Boyoun
Abstract excerpt
BACKGROUND: Recently, the association of a common STAT4 haplotype with type 1 diabetes (T1D) as well as rheumatoid arthritis has been documented in Caucasians and Koreans. STAT4 is involved in the signalling of interleukin-12 and γIFN, as well as interleukin-23. To discover genes affecting the susceptibility of common autoimmune diseases, we studied the association of polymorphisms in STAT4 with autoimmune...
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