Article
A RecA protein mutant deficient in its interaction with the UmuDC complex.
Biochimie - 1 Apr 1991
Bailone A, Sommer S, Knezević J, Dutreix M, Devoret R
Abstract excerpt
recA1730 is a dominant point mutation preventing SOS mutagenesis. We demonstrate here that: i) RecA1730 fails to produce mutagenesis even though UmuD' is formed, ii) recA1730, when complemented by recA+, can cleave LexA protein and it displays a UmuDC- phenotype in spite of adequate concentrations of matured UmuD' and UmuC proteins, iii) the Mut- phenotype caused by RecA1730 is partially alleviated by MucAB...
Topics
- Bacterial Proteins
- DNA Damage
- DNA-Directed DNA Polymerase
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Mutation
- Phenotype
- Rec A Recombinases
- SOS Response, Genetics