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Article

RecA protein of Escherichia coli has a third essential role in SOS mutator activity.

Journal of bacteriology - 1 Jun 1990

Sweasy J B, Witkin E M, Sinha N, Roegner-Maniscalco V

Abstract excerpt

The DNA damage-inducible SOS response of Escherichia coli includes an error-prone translesion DNA replication activity responsible for SOS mutagenesis. In certain recA mutant strains, in which the SOS response is expressed constitutively, SOS mutagenesis is manifested as a mutator activity. Like UV mutagenesis, SOS mutator activity requires the products of the umuDC operon and depends on RecA protein for at least...

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Identifiers

PMID: 2188949
DOI: 10.1128/jb.172.6.3030-3036.1990
PMCID: PMC209104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RecA protein of Escherichia coli has a third essential role in SOS mutator activity.PMID 2188949Read ↗

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Mutations for Worse or Better: Low-Fidelity DNA Synthesis by SOS DNA Polymerase V Is a Tightly Regulated Double-Edged Sword.Semantic proximity Read ↗

Differential cleavage of LexA and UmuD mediated by recA Pro67 mutants: implications for common LexA and UmuD binding sites on RecA.Semantic proximity Read ↗

The isfA mutation inhibits mutator activity and processing of UmuD protein in Escherichia coli recA730 strains.Semantic proximity Read ↗

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DNA polymerase V and RecA protein, a minimal mutasome.Semantic proximity Read ↗

Mutations affecting the ability of the Escherichia coli UmuD' protein to participate in SOS mutagenesis.Semantic proximity Read ↗

Genetic control of the UV-induced SOS mutator effect in single- and double-stranded DNA phages.Semantic proximity Read ↗

Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12.Semantic proximity Read ↗

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