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Article

Mutations for Worse or Better: Low-Fidelity DNA Synthesis by SOS DNA Polymerase V Is a Tightly Regulated Double-Edged Sword.

Biochemistry - 26 Apr 2016

Jaszczur Malgorzata, Bertram Jeffrey G, Robinson Andrew, van Oijen Antoine M, Woodgate Roger, Cox Michael M, Goodman Myron F

Abstract excerpt

1953, the year of Watson and Crick, bore witness to a less acclaimed yet highly influential discovery. Jean Weigle demonstrated that upon infection of Escherichia coli, λ phage deactivated by UV radiation, and thus unable to form progeny, could be reactivated by irradiation of the bacterial host. Evelyn Witkin and Miroslav Radman later revealed the presence of the SOS regulon. The more than 40 regulon genes are...

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Identifiers

PMID: 27043933
DOI: 10.1021/acs.biochem.6b00117
PMCID: PMC4846499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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