Article
DNA polymerase V and RecA protein, a minimal mutasome.
Molecular cell - 18 Feb 2005
Schlacher Katharina, Leslie Kris, Wyman Claire, Woodgate Roger, Cox Michael M, Goodman Myron F
Abstract excerpt
A hallmark of the Escherichia coli SOS response is the large increase in mutations caused by translesion synthesis (TLS). TLS requires DNA polymerase V (UmuD'2C) and RecA. Here, we show that pol V and RecA interact by two distinct mechanisms. First, pol V binds to RecA in the absence of DNA and ATP and second, through its UmuD' subunit, requiring DNA and ATP without ATP hydrolysis. TLS occurs in the absence of a...
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