Article
An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population.
Brain research - 19 Feb 2009
Szvetko Attila L, Jones Ashleigh, Mackenzie Jason, Tajouri Lotti, Csurhes Peter A, Greer Judith M, Pender Michael P, Griffiths Lyn R
Abstract excerpt
Multiple sclerosis (MS) is a common cause of neurological disability in young adults. The disease generally manifests in early to middle adulthood and causes various neurological deficits. Autoreactive T lymphocytes and their associated antigens have long been presumed important features of MS pathogenesis. The Protein tyrosine phosphatase receptor type C gene (PTPRC) encodes the T-cell receptor CD45. Variations...
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