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Article

Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population.

Neuroscience letters - 16 Aug 2002

Ballerini Clara, Rosati Eleonora, Salvetti Marco, Ristori Giovanni, Cannoni Stefania, Biagioli Tiziana, Massacesi Luca, Sorbi Sandro, Vergelli Marco

Abstract excerpt

In this study, we investigate the role of the C-->G mutation in position 77 of exon 4 of the protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding for the CD45 molecule, for the development of multiple sclerosis (MS) in an Italian continental population. The PTPRC mutated genotype has...

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Identifiers

PMID: 12147336
DOI: 10.1016/s0304-3940(02)00565-7

Genes

PTPRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12147336-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population.PMID 12147336Read ↗

CD45 (PTPRC) as a candidate gene in multiple sclerosis.Semantic proximity Read ↗

Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus?Semantic proximity Read ↗

A point mutation in PTPRC is associated with the development of multiple sclerosis.Semantic proximity Read ↗

Enhanced frequency of a PTPRC (CD45) exon A mutation (77C-->G) in systemic sclerosis.Semantic proximity Read ↗

PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.Semantic proximity Read ↗

An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population.Semantic proximity Read ↗

CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers.Semantic proximity Read ↗

No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.Semantic proximity Read ↗

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PTPRC (CD45) variation and disease association studied using single nucleotide polymorphism tagging.Semantic proximity Read ↗

A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population.Semantic proximity Read ↗

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