CTLA4 gene polymorphisms and multiple sclerosis in Northern Ireland.

doi:10.1016/j.jneuroim.2007.04.017

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Article

CTLA4 gene polymorphisms and multiple sclerosis in Northern Ireland.

Journal of neuroimmunology - 1 Jul 2007

Heggarty Shirley, Suppiah Vijayaprakash, Silversides Jonathan, O'doherty Catherine, Droogan Aidan, McDonnell Gavin, Hawkins Stanley, Graham Colin, Vandenbroeck Koen

Abstract excerpt

Four CTLA4 polymorphisms were investigated in a Northern Irish collection of relapsing-remitting (RR) and primary-progressive (PP) multiple sclerosis (MS) patients. The CTLA4 promoter (-318 C/T), exon 1 (+49 A/G) and intergenic CT60 SNPs, as well as a microsatellite found in the 3' UTR (AT(n)) were analysed in 246 RRMS, 84 PPMS and 158 healthy controls. The A allele of the exon 1 +49 A/G SNP (OR=1.36; 95%...

Topics

3' Untranslated Regions
Antigens, CD
Antigens, Differentiation
CTLA-4 Antigen
Confidence Intervals
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Ireland
Microsatellite Repeats
Multiple Sclerosis
Odds Ratio

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

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Open in PubMed

Identifiers

PMID: 17524498
DOI: 10.1016/j.jneuroim.2007.04.017

Genes

CTLA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.