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Article

CD45 (PTPRC) as a candidate gene in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 2004

Vyshkina Tamara, Leist Thomas P, Shugart Yin Yao, Kalman Bernadette

Abstract excerpt

The 77C-->G polymorphism in exon 4 of CD45 or protein tyrosine phosphatase receptor-type C (PTPRC) has been investigated in families with multiple sclerosis (MS) and in several cohorts of sporadic patients and controls, however, with conflicting results. To better understand the role of this functionally important polymorphism in MS, we investigated the transmission of the 'G' allele from unaffected parents to...

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Source

Identifiers

PMID: 15584483
DOI: 10.1191/1352458504ms1115oa

Genes

PTPRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD45 (PTPRC) as a candidate gene in multiple sclerosis.PMID 15584483Read ↗

Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus?Semantic proximity Read ↗

Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population.Semantic proximity Read ↗

A point mutation in PTPRC is associated with the development of multiple sclerosis.Semantic proximity Read ↗

Enhanced frequency of a PTPRC (CD45) exon A mutation (77C-->G) in systemic sclerosis.Semantic proximity Read ↗

PTPRC (CD45) variation and disease association studied using single nucleotide polymorphism tagging.Semantic proximity Read ↗

No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.Semantic proximity Read ↗

PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.Semantic proximity Read ↗

CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers.Semantic proximity Read ↗

An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population.Semantic proximity Read ↗

CD45 isoform expression in autoimmune myasthenia gravis.Semantic proximity Read ↗

A point mutation in CD45 may be associated with an increased risk of HIV-1 infection.Semantic proximity Read ↗

Unusual case presentations associated with the CD45 C77G polymorphism.Semantic proximity Read ↗

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