Article
A point mutation in PTPRC is associated with the development of multiple sclerosis.
Nature genetics - 1 Dec 2000
Jacobsen M, Schweer D, Ziegler A, Gaber R, Schock S, Schwinzer R, Wonigeit K, Lindert R B, Kantarci O, Schaefer-Klein J, Schipper H I, Oertel W H, Heidenreich F, Weinshenker B G, Sommer N, Hemmer B
Abstract excerpt
Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. It is widely accepted that a dysregulated immune response against brain resident antigens is central to its yet unknown pathogenesis. Although there is evidence that the development of MS has a genetic component, specific genetic factors are largely unknown. Here we investigated the role of a point mutation in the gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.