Article
Analysis of polymorphisms of the 2',3'-cyclic nucleotide-3'-phosphodiesterase gene in patients with multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 1996
Thompson R J, Mason C R, Douglas A J, Hinks L J, Dwarswaard A, Price S E
Abstract excerpt
Susceptibility to multiple sclerosis (MS) is widely held to have a genetic component. Possible candidate genes conferring this susceptibility include those coding for proteins specific to central nervous system (CNS) myelin. 2',3'-cyclic nucleotide-3'-phosphodiesterase (CNPase) is an enzyme found at high concentrations in CNS myelin, however its function is unknown. The amino acid sequence of CNPase shows a...
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