No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.

The Journal of rheumatology - 1 Sept 2008

Kirsten Holger, Blume Mechthild, Emmrich Frank, Hunzelmann Nico, Mierau Rudolf, Rzepka Rita, Vaith Peter, Witte Torsten, Melchers Inga, Ahnert Peter

Abstract excerpt

OBJECTIVE: The functional variant C77G (rs17612648) of PTPRC (CD45) was described to confer risk for systemic sclerosis (SSc) in German Caucasians. We analyzed this association in an independent, larger German cohort. METHODS: We genotyped 171 cases and 179 controls. Cases were subgrouped according to sex, autoantibody profiles, or clinical subsets. RESULTS: No association of SSc with C77G was detected in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germany

Share to Leukocyte Common Antigens

Share to Odds Ratio

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Share to Scleroderma, Systemic

Share to White People

Source

Open in PubMed

Identifiers

PMID: 18634151

Genes

PTPRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.PMID 18634151Read ↗

Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus?Semantic proximity Read ↗

PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.Semantic proximity Read ↗

C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease.Semantic proximity Read ↗

PTPRC (CD45) variation and disease association studied using single nucleotide polymorphism tagging.Semantic proximity Read ↗

Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population.Semantic proximity Read ↗

Enhanced frequency of a PTPRC (CD45) exon A mutation (77C-->G) in systemic sclerosis.Semantic proximity Read ↗

CD45 (PTPRC) as a candidate gene in multiple sclerosis.Semantic proximity Read ↗

Lack of association of the PLD4 SNP rs2841277 with systemic sclerosis in a European American population.Semantic proximity Read ↗

A large multicentre analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype.Semantic proximity Read ↗

Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population.Semantic proximity Read ↗

The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype.Semantic proximity Read ↗

Outcome of children treated with haematopoietic-stem cell transplantations from donors expressing the rare C77G variant of the PTPRC (CD45) gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.