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Article

No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort.

Journal of the neurological sciences - 15 Jan 2007

Szvetko A L, Fowdar J, Nelson J, Colson N, Tajouri L, Csurhes P A, Pender M P, Griffiths L R

Abstract excerpt

Multiple sclerosis (MS) is a complex neurological disease that affects the central nervous system (CNS) resulting in debilitating neuropathology. Pathogenesis is primarily defined by CNS inflammation and demyelination of nerve axons. Methionine synthase reductase (MTRR) is an enzyme that catalyzes the remethylation of homocysteine (Hcy) to methionine via cobalamin and folate dependant reactions. Cobalamin acts as...

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Source

Identifiers

PMID: 17113603
DOI: 10.1016/j.jns.2006.10.006

Genes

MTRR
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort.PMID 17113603Read ↗

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis.Semantic proximity Read ↗

Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients.Semantic proximity Read ↗

Genetic variants of homocysteine metabolism and multiple sclerosis: a case-control study.Semantic proximity Read ↗

Genetic variants of folate metabolism and the risk of multiple sclerosis.Semantic proximity Read ↗

The variant methylenetetrahydrofolate reductase c.1298A>C (p.E429A) is associated with multiple sclerosis in a German case-control study.Semantic proximity Read ↗

An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population.Semantic proximity Read ↗

The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations.Semantic proximity Read ↗

Analysis of the NRAMP1 gene implicated in iron transport: association with multiple sclerosis and age effects.Semantic proximity Read ↗

Detection of MTRR 66A-->G polymorphism using the real-time polymerase chain reaction machine LightCycler for determination of composition of allele after restriction cleavage.Semantic proximity Read ↗

Inflammatory profile, age of onset, and the MTHFR polymorphism in patients with multiple sclerosis.Semantic proximity Read ↗

Methionine synthase reductase MTRR 66A > G has no effect on total homocysteine, folate, and Vitamin B12 concentrations in renal transplant patients.Semantic proximity Read ↗

Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia.Semantic proximity Read ↗

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