Article
Investigation of the [-/A]8 and C1236T genetic variations within the human Toll-like receptor 3 gene for association with multiple sclerosis.
Neurological research - 1 May 2010
Szvetko Attila L, Jones Ashleigh, Mackenzie Jason, Tajouri Lotti, Csurhes Peter A, Greer Judith M, Pender Michael P, Griffiths Lyn R
Abstract excerpt
Multiple sclerosis (MS) is a serious cause of neurological disability among young adults. The clinical course remains difficult to predict, and the pathogenesis of the disease is still modestly understood. Autoimmunity is thought to be a key aspect of the disease, with autoreactive T cells thought to mediate central nervous system (CNS) inflammation to some extent. Toll-like receptors are known to mediate...
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