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Article

PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.

Journal of neurology - 1 Sept 2004

Cocco Eleonora, Murru Maria Rita, Melis Cristina, Schirru Lucia, Solla Elisabetta, Lai Marina, Rolesu Marcella, Marrosu Maria Giovanna

Abstract excerpt

A linkage and association of the CD45 (protein-tyrosine phosphatase, receptor-type C) C77G polymorphism and multiple sclerosis (MS) has been found in some studies but not in others. We analysed the C77G polymorphism in MS patients from the genetically homogeneous population of Sardinia. Using the transmission disequilibrium test, the mutation has been sought in 241 patients and 217 healthy sibs (HS) from...

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Identifiers

PMID: 15372250
DOI: 10.1007/s00415-004-0485-1

Genes

PTPRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.PMID 15372250Read ↗

No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.Semantic proximity Read ↗

Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population.Semantic proximity Read ↗

Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus?Semantic proximity Read ↗

Lack of evidence for a role of the myelin basic protein gene in multiple sclerosis susceptibility in Sardinian patients.Semantic proximity Read ↗

DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population.Semantic proximity Read ↗

An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population.Semantic proximity Read ↗

CD45 (PTPRC) as a candidate gene in multiple sclerosis.Semantic proximity Read ↗

Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia.Semantic proximity Read ↗

Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients.Semantic proximity Read ↗

CD45 isoform expression in autoimmune myasthenia gravis.Semantic proximity Read ↗

Enhanced frequency of a PTPRC (CD45) exon A mutation (77C-->G) in systemic sclerosis.Semantic proximity Read ↗

C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease.Semantic proximity Read ↗

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