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Article

Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus?

Nature genetics - 1 Sept 2001

Vorechovsky I, Kralovicova J, Tchilian E, Masterman T, Zhang Z, Ferry B, Misbah S, Chapel H, Webster D, Hellgren D, Anvret M, Hillert J, Hammarstrom L, Beverley P C

Abstract excerpt

A 77G allele of the gene encoding CD45, also known as the protein tyrosine phosphatase receptor-type C gene (PTPRC), has been associated with multiple sclerosis (MS). Here we determine allele frequencies in large numbers of MS patients, primary immunodeficiencies linked to major histocompatibility complex (MHC) locus and over 1,000 controls to assess whether aberrant splicing of PTPRC caused by the 77C-->G...

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Share to Autoimmune Diseases
Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocyte Common Antigens

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Source

Identifiers

PMID: 11548742
DOI: 10.1038/ng723

Genes

PTPRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus?PMID 11548742Read ↗

CD45 (PTPRC) as a candidate gene in multiple sclerosis.Semantic proximity Read ↗

No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.Semantic proximity Read ↗

Enhanced frequency of a PTPRC (CD45) exon A mutation (77C-->G) in systemic sclerosis.Semantic proximity Read ↗

Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population.Semantic proximity Read ↗

A point mutation in PTPRC is associated with the development of multiple sclerosis.Semantic proximity Read ↗

An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population.Semantic proximity Read ↗

A point mutation in CD45 may be associated with an increased risk of HIV-1 infection.Semantic proximity Read ↗

Disease associations and altered immune function in CD45 138G variant carriers.Semantic proximity Read ↗

PTPRC (CD45) variation and disease association studied using single nucleotide polymorphism tagging.Semantic proximity Read ↗

PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.Semantic proximity Read ↗

CD45 isoform expression in autoimmune myasthenia gravis.Semantic proximity Read ↗

CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers.Semantic proximity Read ↗

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