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Article

The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish.

Current biology : CB - 9 Dec 2008

Osborne Nick, Brand-Arzamendi Koroboshka, Ober Elke A, Jin Suk-Won, Verkade Heather, Holtzman Nathalia Glickman, Yelon Deborah, Stainier Didier Y R

Abstract excerpt

The bioactive lipid sphingosine 1-phosphate (S1P) and its G protein-coupled receptors play critical roles in cardiovascular, immunological, and neural development and function. Despite its importance, many questions remain about S1P signaling, including how S1P, which is synthesized intracellularly, is released from cells. Mutations in the zebrafish gene encoding the S1P receptor Miles Apart (Mil)/S1P(2) disrupt...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19062281
DOI: 10.1016/j.cub.2008.10.061
PMCID: PMC2741689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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