Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spinsters, synaptic defects, and amaurotic idiocy.

Neuron - 24 Oct 2002

Sanyal Subhabrata, Ramaswami Mani

Abstract excerpt

In this issue of Neuron, Sweeney and Davis present a beautiful characterization of Drosophila mutants in a gene named spinster. The results indicate a function of the endocytic pathway in regulating transforming growth factor-beta (TGF-beta) signaling at the Drosophila motor synapse. This study provides important new information at an intersection of several disciplines, including membrane traffic, lipid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila melanogaster
Share to Drosophila Proteins
Share to Endocytosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Neuromuscular Junction

Share to Signal Transduction

Share to Synaptic Transmission

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 12408836
DOI: 10.1016/s0896-6273(02)01015-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spinsters, synaptic defects, and amaurotic idiocy.PMID 12408836Read ↗

Lipid metabolic perturbation is an early-onset phenotype in adult spinster mutants: a Drosophila model for lysosomal storage disorders.Semantic proximity Read ↗

Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation.Semantic proximity Read ↗

Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster.Semantic proximity Read ↗

Lipid metabolic perturbation is an early-onset phenotype in adult <i>spin</i> mutants: a <i>Drosophila</i> model for lysosomal storage disordersSemantic proximity Read ↗

A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline.Semantic proximity Read ↗

Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases.Semantic proximity Read ↗

A Saposin deficiency model in <i>Drosophila</i> : lysosomal storage, progressive neurodegeneration, sensory physiological decline and defective calcium homeostasisSemantic proximity Read ↗

Tweek-dependent formation of ER-PM contact sites enables astrocyte phagocytic function and remodeling of neuronsSemantic proximity Read ↗

Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function.Semantic proximity Read ↗

Lipid Disbalance Affects Neuronal Dendrite Growth and Maintenance in a Human Ceramide Synthase Disease ModelSemantic proximity Read ↗

Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases.Semantic proximity Read ↗

Dopey-dependent regulation of extracellular vesicles maintains neuronal morphologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.