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Article

Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.

Biochemistry - 27 Jan 2015

Burczyk Martina, Burkhalter Martin D, Blätte Tamara, Matysik Sabrina, Caron Marc G, Barak Lawrence S, Philipp Melanie

Abstract excerpt

The evolutionarily conserved DRY motif at the end of the third helix of rhodopsin-like, class-A G protein-coupled receptors (GPCRs) is a major regulator of receptor stability, signaling activity, and β-arrestin-mediated internalization. Substitution of the DRY arginine with histidine in the human vasopressin receptor results in a loss-of-function phenotype associated with diabetes insipidus. The analogous R150H...

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Identifiers

PMID: 25555130
DOI: 10.1021/bi501061h
PMCID: PMC4310627

Genes

GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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