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Article

Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels.

PloS one - 1 Jan 2018

Riento Kirsi, Zhang Qifeng, Clark Jonathan, Begum Farida, Stephens Elaine, Wakelam Michael J, Nichols Benjamin J

Abstract excerpt

Sphingosine-1-phosphate (S1P) is an important lipid signalling molecule. S1P is produced via intracellular phosphorylation of sphingosine (Sph). As a lipid with a single fatty alkyl chain, Sph may diffuse rapidly between cellular membranes and through the aqueous phase. Here, we show that the absence of microdomains generated by multimeric assemblies of flotillin proteins results in reduced S1P levels. Cellular...

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Identifiers

PMID: 29787576
DOI: 10.1371/journal.pone.0197401
PMCID: PMC5963794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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