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Article

The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2008

Astapova Inna, Lee Larissa J, Morales Crystal, Tauber Stefanie, Bilban Martin, Hollenberg Anthony N

Abstract excerpt

The thyroid hormone receptor (TR) has been proposed to regulate expression of target genes in the absence of triiodothyronine (T(3)) through the recruitment of the corepressors, NCoR and SMRT. Thus, NCoR and SMRT may play an essential role in thyroid hormone action, although this has never been tested in vivo. To accomplish this, we developed mice that express in the liver a mutant NCoR protein (L-NCoRDeltaID)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19052228
DOI: 10.1073/pnas.0804604105
PMCID: PMC2614797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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