Article

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

2022-03-28

Abstract excerpt

FOXP3 + regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states. Upon NCOR1 deletion in T cells, effector Treg cell frequencies were elevated in mice and in in vitro -generated human Treg cells. NCOR1-deficient Treg cells failed to protect mice from severe weight loss and intestinal inflammation assoc...

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Literature Corpus work: 4e7f5e1a-afb7-5025-aafb-1e2a2ab0d966
DOI: 10.1101/2022.03.24.485609

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