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Article

Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.

Molecular and cellular biology - 1 May 2014

Vella Kristen R, Ramadoss Preeti, Costa-E-Sousa Ricardo H, Astapova Inna, Ye Felix D, Holtz Kaila A, Harris Jamie C, Hollenberg Anthony N

Abstract excerpt

Resistance to thyroid hormone (RTH), a human syndrome, is characterized by high thyroid hormone (TH) and thyroid-stimulating hormone (TSH) levels. Mice with mutations in the thyroid hormone receptor beta (TRβ) gene that cannot bind steroid receptor coactivator 1 (SRC-1) and Src-1(-/-) mice both have phenotypes similar to that of RTH. Conversely, mice expressing a mutant nuclear corepressor 1 (Ncor1) allele that...

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Source

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Identifiers

PMID: 24550004
DOI: 10.1128/MCB.00129-14
PMCID: PMC3993596

Genes

SRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.PMID 24550004Read ↗

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