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Article

Differential recruitment of nuclear coregulators directs the isoform-dependent action of mutant thyroid hormone receptors.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 2011

Fozzatti Laura, Lu Changxue, Kim Dong-Wook, Cheng Sheue-yann

Abstract excerpt

Studies using mice deficient in thyroid hormone receptors (TR) indicate that the two TR isoforms, TRα1 and TRβ1, in addition to mediating overlapping biological activities of the thyroid hormone, T3, also mediate distinct functions. Mice harboring an identical dominant negative mutation (denoted PV) at the C terminus of TRα1 (Thra1(PV) mice) or β1 (Thrb(PV) mice) also exhibit distinct phenotypes. These knockin...

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Identifiers

PMID: 21474540
DOI: 10.1210/me.2010-0474
PMCID: PMC3100599

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