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Article

Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression.

Molecular and cellular biology - 1 Aug 2003

Wagner Brandee L, Valledor Annabel F, Shao Gang, Daige Chris L, Bischoff Eric D, Petrowski Mary, Jepsen Kristen, Baek Sung Hee, Heyman Richard A, Rosenfeld Michael G, Schulman Ira G, Glass Christopher K

Abstract excerpt

Liver X receptors (LXRs) regulate the expression of genes involved in cholesterol and fatty acid homeostasis, including the genes for ATP-binding cassette transporter A1 (ABCA1) and sterol response element binding protein 1 (SREBP1). Loss of LXR leads to derepression of the ABCA1 gene in macropha...

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Identifiers

PMID: 12897148
DOI: 10.1128/MCB.23.16.5780-5789.2003
PMCID: PMC166346

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12897148-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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