Article
NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor.
Proceedings of the National Academy of Sciences of the United States of America - 3 Oct 2017
Mendoza Arturo, Astapova Inna, Shimizu Hiroaki, Gallop Molly R, Al-Sowaimel Lujain, MacGowan S M Dileas, Bergmann Tim, Berg Anders H, Tenen Danielle E, Jacobs Christopher, Lyubetskaya Anna, Tsai Linus, Hollenberg Anthony N
Abstract excerpt
Nuclear receptor corepressor 1 (NCoR1) is considered to be the major corepressor that mediates ligand-independent actions of the thyroid hormone receptor (TR) during development and in hypothyroidism. We tested this by expressing a hypomorphic NCoR1 allele (NCoR1ΔID), which cannot interact with the TR, in Pax8-KO mice, which make no thyroid hormone. Surprisingly, abrogation of NCoR1 function did not reverse the...
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