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Article

Corepressor SMRT functions as a coactivator for thyroid hormone receptor T3Ralpha from a negative hormone response element.

The Journal of biological chemistry - 20 Dec 2002

Berghagen Hege, Ragnhildstveit Erlend, Krogsrud Kristin, Thuestad Gunnar, Apriletti James, Saatcioglu Fahri

Abstract excerpt

Nuclear receptors are ligand-modulated transcription factors that transduce the presence of lipophilic ligands into changes in gene expression. Nuclear receptor activity is regulated by ligand-induced interactions with coactivator or corepressor molecules. From a positive hormone response element (pHRE) and in the absence of hormone, corepressors SMRT and N-CoR are bound to some nuclear receptors such as the...

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PMID: 12388540
DOI: 10.1074/jbc.M209546200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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