Article
The nuclear corepressors recognize distinct nuclear receptor complexes.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 2000
Cohen R N, Putney A, Wondisford F E, Hollenberg A N
Abstract excerpt
The thyroid hormone receptor (TR) and retinoic acid receptor (RAR) isoforms have the capacity to silence gene expression in the absence of their ligands on target response elements. This active repression is mediated by the ability of the corepressors, nuclear receptor corepressor (NCoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT), to recruit a complex containing histone deacetylase...
Topics
- Binding Sites
- Cell Line
- Cell Nucleus
- DNA-Binding Proteins
- Dimerization
- Glutathione Transferase
- Mutation
- Nuclear Proteins
- Nuclear Receptor Co-Repressor 1
- Nuclear Receptor Co-Repressor 2
- Receptors, Retinoic Acid
- Receptors, Thyroid Hormone
- Recombinant Fusion Proteins
- Repressor Proteins
- Response Elements
- Retinoid X Receptors
- Thyroid Hormone Resistance Syndrome
- Transcription Factors