Article
DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia.
Biological psychology - 1 Sept 2008
Szeszko Philip R, Hodgkinson Colin A, Robinson Delbert G, Derosse Pamela, Bilder Robert M, Lencz Todd, Burdick Katherine E, Napolitano Barbara, Betensky Julia D, Kane John M, Goldman David, Malhotra Anil K
Abstract excerpt
BACKGROUND: DISC1 is considered a susceptibility gene for schizophrenia and schizoaffective disorder, but little is known regarding the potential mechanisms through which it may confer increased risk. Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology....
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