Article
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling.
Human molecular genetics - 15 Oct 2006
Hashimoto Ryota, Numakawa Tadahiro, Ohnishi Takashi, Kumamaru Emi, Yagasaki Yuki, Ishimoto Tetsuya, Mori Takeyuki, Nemoto Kiyotaka, Adachi Naoki, Izumi Aiko, Chiba Sachie, Noguchi Hiroko, Suzuki Tatsuyo, Iwata Nakao, Ozaki Norio, Taguchi Takahisa, Kamiya Atsushi, Kosuga Asako, Tatsumi Masahiko, Kamijima Kunitoshi, Weinberger Daniel R, Sawa Akira, Kunugi Hiroshi
Abstract excerpt
Disrupted-in-schizophrenia 1 (DISC1), identified in a pedigree with a familial psychosis with the chromosome translocation (1:11), is a putative susceptibility gene for psychoses such as schizophrenia and bipolar disorder. Although there are a number of patients with major depressive disorder (MDD) in the family members with the chromosome translocation, the possible association with MDD has not yet been studied....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.