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Article

Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

PLoS computational biology - 1 Nov 2008

Carlson Jonathan M, Brumme Zabrina L, Rousseau Christine M, Brumme Chanson J, Matthews Philippa, Kadie Carl, Mullins James I, Walker Bruce D, Harrigan P Richard, Goulder Philip J R, Heckerman David

Abstract excerpt

HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among individuals with similar human leukocyte antigen (HLA) class I alleles, previous population-based studies have been limited by the inability to simultaneously account for HIV codon covariation, linkage disequilibrium among...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 19023406
DOI: 10.1371/journal.pcbi.1000225
PMCID: PMC2579584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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