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Inferring HIV Escape Rates from Multi-Locus Genotype Data

1 Jan 2013

Abstract excerpt

Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex molecules on the surface of virally infected cells and generate an anti-viral response that can kill the infected cells. Virus variants whose protein fragments are not efficiently presented on infected cells or whose fragments are presented but not recognized by CTLs therefore have a competitive...

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PMID: 24027569
DOI: 10.3389/fimmu.2013.00252

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