Article
Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
PloS one - 1 Sept 2010
Rolland Morgane, Carlson Jonathan M, Manocheewa Siriphan, Swain J Victor, Lanxon-Cookson Erinn, Deng Wenjie, Rousseau Christine M, Raugi Dana N, Learn Gerald H, Maust Brandon S, Coovadia Hoosen, Ndung'u Thumbi, Goulder Philip J R, Walker Bruce D, Brander Christian, Heckerman David E, Mullins James I
Abstract excerpt
BACKGROUND: Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evolutionary pathways, we investigated AA co-variation in Gag sequences obtained from 449 South African individuals...
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