Article
Founder effects in the assessment of HIV polymorphisms and HLA allele associations.
Science (New York, N.Y.) - 16 Mar 2007
Bhattacharya Tanmoy, Daniels Marcus, Heckerman David, Foley Brian, Frahm Nicole, Kadie Carl, Carlson Jonathan, Yusim Karina, McMahon Ben, Gaschen Brian, Mallal Simon, Mullins James I, Nickle David C, Herbeck Joshua, Rousseau Christine, Learn Gerald H, Miura Toshiyuki, Brander Christian, Walker Bruce, Korber Bette
Abstract excerpt
Escape from T cell-mediated immune responses affects the ongoing evolution of rapidly evolving viruses such as HIV. By applying statistical approaches that account for phylogenetic relationships among viral sequences, we show that viral lineage effects rather than immune escape often explain apparent human leukocyte antigen (HLA)-mediated immune-escape mutations defined by older analysis methods. Phylogenetically...
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