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Article

HIV-1 subtype B protease and reverse transcriptase amino acid covariation.

PLoS computational biology - 1 May 2007

Rhee Soo-Yon, Liu Tommy F, Holmes Susan P, Shafer Robert W

Abstract excerpt

Despite the high degree of HIV-1 protease and reverse transcriptase (RT) mutation in the setting of antiretroviral therapy, the spectrum of possible virus variants appears to be limited by patterns of amino acid covariation. We analyzed patterns of amino acid covariation in protease and RT sequences from more than 7,000 persons infected with HIV-1 subtype B viruses obtained from the Stanford HIV Drug Resistance...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17500586
DOI: 10.1371/journal.pcbi.0030087
PMCID: PMC1866358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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