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Article

Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.

Journal of virology - 1 May 2012

Carlson Jonathan M, Listgarten Jennifer, Pfeifer Nico, Tan Vincent, Kadie Carl, Walker Bruce D, Ndung'u Thumbi, Shapiro Roger, Frater John, Brumme Zabrina L, Goulder Philip J R, Heckerman David

Abstract excerpt

The promiscuous presentation of epitopes by similar HLA class I alleles holds promise for a universal T-cell-based HIV-1 vaccine. However, in some instances, cytotoxic T lymphocytes (CTL) restricted by HLA alleles with similar or identical binding motifs are known to target epitopes at different frequencies, with different functional avidities and with different apparent clinical outcomes. Such differences may be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22379086
DOI: 10.1128/JVI.06728-11
PMCID: PMC3347390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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