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Article

Mutated interleukin-5 monomers are biologically inactive.

Molecular immunology - 1 Jan 2000

McKenzie A N, Ely B, Sanderson C J

Abstract excerpt

Interleukin-5 contains only two cysteine residues both of which appear to be involved in the dimerisation of the molecule to form a disulphide-linked homodimer (Minamitake et al., J. Biochem. 107, 292-297, 1990). However, it remains unclear whether this linkage is necessary for the bioactivity of this cytokine. Site-directed mutagenesis was used to produce amino acid substitutions of either or both of the...

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PMID: 1901378
DOI: 10.1016/0161-5890(91)90099-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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