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Article

Importance of the carboxy-terminus of human interleukin-11 in conserving its biological activity.

Bioscience, biotechnology, and biochemistry - 1 Mar 1996

Miyadai K, Ohsumi J, Yoshimura C, Kawashima I, Ito Y

Abstract excerpt

Biological activities of the carboxy-terminal (C-terminal) deletion mutants of human interleukin-11 (IL-11) were analyzed. Removal of only 1 amino-acid residue (leucine) from the C-terminus caused nearly an 80% loss of its biological activity. This shows the importance of C-terminus of human IL-11 in terms of conserving the biological activity.

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Identifiers

PMID: 8901120
DOI: 10.1271/bbb.60.541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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